Just one or various drug overdose with oxycodone and acetaminophen is really a possibly lethal polydrug overdose, and consultation using a regional poison Command Heart is usually recommended.The subsequent are clinically substantial drug interactions with oxycodone. This isn't an all-inclusive checklist — other medication not stated right here m

Oral Contraceptives: Boost in glucuronidation leading to elevated plasma clearance plus a reduced fifty percent-lifetime of acetaminophen.Acetaminophen is metabolized within the liver by using cytochrome P450 microsomal enzyme. About 8085% in the acetaminophen in the body is conjugated principally with glucuronic acid also to a lesser extent with s